Giving Up

I've read this quote from Grey's Anatomy: 

Because in every relationship there comes a point when the damage is too much and no matter how good it once was, the memories can't sustain you. You have to save yourself knowing all the while it will hurt like hell. Because you can't keep giving someone everything if you get nothing in return...

When do you say it's over? When do you give up,  raise the white flag and surrender? When the damage is too much, dreams are shattered and everything else is broken?  It really hurts to give up and it is really never easy. And you even come to the point that giving up is the last thing that you can do.. Losing everything that means everything to you.. It's like losing someone you never had.. It's heart-breaking but it's true. I'm not saying that once we are hurt, we will just give up easily. I believe that we should not end the relationship right away. We have to make sure that we have done whatever is possible to make it work. But if you have given everything but you got nothing in return as what the quote says, then that is the time for you to let go. No excuses. Just let go. No "holding on" anymore, not even to a single happy memory. That's the only way that you can help yourself from the mess that you're in. That's the only way that you can move on and find love again ...